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Related Experiment Videos

Ergotamine and cerebral blood flow

V Hachinski, J W Norris, J Edmeads

    Stroke
    |November 1, 1978
    PubMed
    Summary

    Ergotamine tartrate, used therapeutically, does not alter cerebral blood flow (CBF) in patients. This study found no significant changes in brain circulation even when ergotamine relieved headaches in migraineurs.

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    Area of Science:

    • Neurology
    • Pharmacology
    • Cerebrovascular Physiology

    Background:

    • Cerebral blood flow (CBF) is crucial for brain function.
    • Ergotamine tartrate is a medication often used for migraines.
    • Understanding ergotamine's effect on cerebral circulation is important for patient care.

    Purpose of the Study:

    • To investigate the impact of ergotamine tartrate on cerebral blood flow.
    • To determine if therapeutic doses of ergotamine tartrate affect regional and hemispheric CBF.
    • To assess ergotamine's cerebrovascular effects, particularly in migraine patients experiencing headache relief.

    Main Methods:

    • Cerebral blood flow (CBF) was measured in 16 patients.
    • The xenon-133 intracarotid method was employed for CBF measurement.
    • Measurements were taken before and after intramuscular injection of ergotamine tartrate.

    Main Results:

    • Intramuscular injection of ergotamine tartrate did not alter regional or hemispheric CBF.
    • No significant changes in cerebral circulation were observed in any patient.
    • CBF remained unaltered even in three migraineurs whose headaches were relieved by ergotamine.

    Conclusions:

    • Therapeutic doses of ergotamine tartrate have no discernible effect on the cerebral circulation.
    • Ergotamine tartrate does not impact overall brain blood flow in patients.
    • The study suggests ergotamine's mechanism for headache relief does not involve alterations in cerebral hemodynamics.

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