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Related Experiment Videos

The Sternberg-Reed cell: mononuclear, multinucleated or multilobated?

N Buyssens, N Bourgeois

    Virchows Archiv. A, Pathological Anatomy and Histology
    |January 1, 1980
    PubMed
    Summary

    This study examined Sternberg-Reed cells, revealing that mononuclear cells can possess composite nuclei. These findings clarify the cell morphology and relationships in certain conditions.

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    Area of Science:

    • Hematology
    • Cell Biology
    • Pathology

    Background:

    • Sternberg-Reed cells are characteristic of certain hematologic malignancies.
    • Understanding their morphology is crucial for accurate diagnosis.

    Purpose of the Study:

    • To investigate the relationship between mononuclear, multinucleated, and multilobated Sternberg-Reed cells.
    • To characterize nuclear morphology in these cells.

    Main Methods:

    • Three-dimensional reconstructions were performed on serial sections of Sternberg-Reed cells.
    • Sections were 1-2 microns thick.

    Main Results:

    • Twenty-one Sternberg-Reed cells were analyzed.
    • Seven cells were binucleated with composite nuclei.
    • Eight cells were mononuclear with composite nuclei, and six were mononuclear with single nuclei.

    Conclusions:

    • Mononuclear Sternberg-Reed cells can exhibit composite nuclei.
    • This suggests a potential developmental or morphological continuum among Sternberg-Reed cell forms.

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