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Xenobiotic triglyceride formation

J V Crayford, D H Hutson

    Xenobiotica; the Fate of Foreign Compounds in Biological Systems
    |May 1, 1980
    PubMed
    Summary

    Skin residue analysis of 3-phenoxybenzoic acid in rats revealed that neutral metabolites, including 2- and 3-(3-phenoxybenzoyl)dipalmitins, accumulate over time, with higher doses leading to a greater proportion of these neutral compounds.

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    Area of Science:

    • Toxicology
    • Pharmacokinetics
    • Dermal Absorption Studies

    Background:

    • Understanding the metabolic fate of xenobiotics is crucial for risk assessment.
    • Skin can act as a reservoir for chemical residues.
    • 3-Phenoxybenzoic acid is a chemical compound with potential toxicological implications.

    Purpose of the Study:

    • To investigate the residue distribution and metabolic profile of 3-phenoxybenzoic acid in rat skin.
    • To identify the chemical nature of metabolites present in the skin.
    • To evaluate the impact of dosage on residue composition.

    Main Methods:

    • Oral administration of radiolabeled 3-phenoxybenzoic acid to rats.
    • Skin tissue extraction and radioactivity measurement.
    • Chromatographic separation (gel permeation, absorption, TLC) and mass spectrometry for metabolite identification.

    Main Results:

    • Low percentages (1-3%) of administered radioactivity were found in rat skin four days post-dosing.
    • Residues consisted of unchanged 3-phenoxybenzoic acid and neutral metabolites.
    • Higher doses resulted in a greater proportion of neutral metabolites (up to 60%), identified as 2- and 3-(3-phenoxybenzoyl)dipalmitins.

    Conclusions:

    • The skin retains 3-phenoxybenzoic acid and its metabolites.
    • Neutral metabolites, particularly dipalmitin esters, are significant components of the skin residue.
    • Dosage influences the ratio of parent compound to metabolites in skin.

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