The effect of heparin on lipid metabolism in acute experimental pancreatitis (AEP)

In 22 dogs with acute experimental pancreatitis (AEP) the blood triglyceride (TG) levels, plasma post heparin lipolytic activity (PHLA), plasma inhibitors of PHLA and lipid electrophoresis were estimated. AEP was induced by injection of bile salts and thrombin into the pancreatic duct. In dogs treated with heparin in doses of 1.5 mg/kg body weight, hyperlipaemia was not found. In these animals the increase of PHLA inhibitors was evidently lower in comparison to untreated group. Our results indicate the preventive effect of heparin against disturbances of lipid metabolism in AEP.