[Place of clinical and pharmacokinetic parameters in prognosing the effectiveness of schizophrenic therapy]

A possibility has been studied of using certain clinical and pharmacokinetical parameters for the individual prediction of chlorpromazine efficacy in 25 schizophrenic patients with different degrees of progression. It was established that the most informative clinical parameter of a successful treatment prognosis is the disease course, polymorphic character of the structure in the prevalent syndrome with a generalization of disorders and an absence of delusional systematizations, a relatively low level of negative personality changes, alternating character of affective disorders in the initial stage of the disease and a certain development of the mental state after a single administration of a control dose of chlorpromazine. Assessment of the pharmacokinetic parameters was provided by the use of a mathematical modelling of pharmacokinetic processes. The most informative pharmacokinetic parameter was the period of half-life of the drug and the constant of the penetration rate from the intestine into blood.