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Experimental murine amyloidosis. Evaluation of induction methods and strain difference
Acta Pathologica Japonica
|July 1, 1980
Summary
Experimental amyloidosis induction in mice depends heavily on the specific mouse strain and the chosen experimental method. Casein injections and Freund
Area of Science:
- Immunology
- Pathology
- Animal Models
Background:
- Murine amyloidosis is a condition studied using experimental models.
- Understanding the factors influencing amyloidosis induction is crucial for research.
Purpose of the Study:
- To evaluate the efficacy of different experimental methods for inducing murine amyloidosis.
- To identify key factors, such as mouse strain and induction technique, that affect successful amyloidosis development.
Main Methods:
- Testing six different mouse strains, including congenital asplenic and athymic nude mice.
- Utilizing casein injections and complete Freund's adjuvant with Mycobacterium butyricum as induction methods.
- Administering multiple injections at weekly intervals.
Main Results:
- Casein injections failed to induce amyloidosis in C3H/He mice.
- Freund's adjuvant injections were ineffective in C3H/He, BALB/c, and ICR/SLC mice.
- Successful amyloidosis induction was observed in CBA mice with Freund's adjuvant, but not in athymic nude or asplenic mice.
Conclusions:
- The success of experimental amyloidosis induction in mice is highly dependent on the specific mouse strain utilized.
- The chosen induction method plays a critical role in the development of experimental amyloidosis.
- Certain mouse strains and immunological statuses (e.g., athymic, asplenic) exhibit resistance to amyloidosis induction.