Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Staphylococcus aureus sepsis in childhood malignancy

J S Miser, A W Miser

    American Journal of Diseases of Children (1960)
    |September 1, 1980
    PubMed
    Summary

    Staphylococcus aureus septicemia in children with cancer is often linked to fever and neutropenia. While single-organism Staphylococcus aureus sepsis has a low mortality rate, multiple-organism sepsis is frequently fatal.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Isolation in real life: lessons from MERS-CoV in Thailand.

    The Journal of hospital infection·2016
    Same author

    Assessment and treatment of pain in children with cancer.

    Anesthesia progress·2009
    Same author

    Prospective randomized trial between two doses of granulocyte colony-stimulating factor after ifosfamide, carboplatin, and etoposide in children with recurrent or refractory solid tumors: a children's cancer group report.

    Journal of pediatric hematology/oncology·2001
    Same author

    Successful dose-intensive treatment of desmoplastic small round cell tumor in three children.

    Journal of pediatric hematology/oncology·2000
    Same author

    Ewing sarcoma of the rib: results of an intergroup study with analysis of outcome by timing of resection.

    The Journal of thoracic and cardiovascular surgery·2000
    Same author

    Granulocyte colony stimulating factor permits dose intensification by interval compression in the treatment of Ewing's sarcomas and soft tissue sarcomas in children.

    European journal of cancer (Oxford, England : 1990)·2000

    Area of Science:

    • Pediatric Oncology
    • Infectious Diseases
    • Hematology

    Background:

    • Children with malignant neoplasms are susceptible to bloodstream infections.
    • Staphylococcus aureus is a common pathogen in healthcare-associated infections.

    Purpose of the Study:

    • To investigate the characteristics and outcomes of Staphylococcus aureus septicemia in pediatric cancer patients.
    • To identify risk factors and complications associated with Staphylococcus aureus bloodstream infections in this vulnerable population.

    Main Methods:

    • Retrospective review of 45 episodes of Staphylococcus aureus septicemia in 44 children with cancer over seven years.
    • Analysis of clinical findings, infection focus, co-infections, complications, and mortality.

    Main Results:

    • Fever, neutropenia, and active malignancy were common at diagnosis.
    • A primary infection focus was identified in 58% of episodes.
    • Multiple-organism sepsis occurred in 4 instances, resulting in 3 deaths.
    • Single-organism Staphylococcus aureus sepsis had a 2% mortality rate.
    • Direct infectious complications occurred in 20% of episodes, with endocarditis and osteomyelitis notably absent.

    Conclusions:

    • Staphylococcus aureus septicemia in pediatric cancer patients presents with specific clinical features.
    • Prompt identification and management of infection focus are crucial.
    • While single-organism S. aureus sepsis is often treatable, polymicrobial sepsis poses a significant threat, necessitating aggressive therapeutic strategies.

    Related Experiment Videos