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[Acute post-traumatic lung failure - morphological evaluation (author's transl)]

G Schlag, W H Voigt, H Redl

    Anasthesie, Intensivtherapie, Notfallmedizin
    |August 1, 1980
    PubMed
    Summary
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    Early lung changes in shock involve leucostasis and edema, potentially preventable with timely treatment. Later stages show fibrosis and impaired gas exchange, characteristic of "shock lung."

    Area of Science:

    • Pathology
    • Experimental Medicine
    • Pulmonology

    Background:

    • Post-traumatic progressive lung failure can occur without direct lung injury.
    • Understanding early morphological changes is crucial for intervention.

    Purpose of the Study:

    • To investigate and reproduce morphological changes of post-traumatic lung failure in an animal model.
    • To identify key phases and cellular events in shock lung development.

    Main Methods:

    • Examination of human lung and muscle biopsy samples.
    • Induction of hypovolemic-traumatic shock in animal models to mimic human findings.
    • Morphological analysis of lung tissue.

    Main Results:

    • Identified two phases: early (leucostasis, endothelial swelling, edema) and late ("shock lung" with fibrosis, impaired gas exchange).

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  • Early changes, particularly leucostasis, were reproducible in animal models.
  • Microthrombi were absent in the early phase.

    • Conclusions:

    • Early intervention targeting leucostasis and edema may prevent "shock lung."
    • The animal model facilitates testing of new prophylactic and therapeutic strategies.
    • This research aids in advancing the treatment of progressive post-traumatic lung failure.