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Delayed hypersensitivity and febrile acne conglobata

Acta Dermato-Venereologica

|January 1, 1977

Summary

Patients with febrile acne conglobata showed impaired delayed hypersensitivity reactions, indicated by negative skin tests to common allergens and tuberculin. Lymphocyte transformation via phytohaemagglutinin (PHA) remained normal, suggesting a specific defect in cellular immunity.

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Area of Science:

Dermatology
Immunology
Cellular Biology

Background:

Febrile acne conglobata is a severe inflammatory skin condition.
Delayed hypersensitivity reactions are crucial for cellular immune responses.
Impaired immune function may contribute to the pathogenesis of acne conglobata.

Purpose of the Study:

To investigate delayed hypersensitivity reactions in patients with febrile acne conglobata.
To compare immune responses in acne conglobata patients with healthy controls.
To assess lymphocyte responsiveness to mitogens in affected individuals.

Main Methods:

Skin testing with tuberculin, Schick toxin, oidiomycin, trichophytin, and 25 common contact allergens.
Assessment of sensitization to 2,4-dinitrochlorobenzene (DNCB).
In vitro lymphocyte transformation assay using phytohaemagglutinin (PHA).

Main Results:

Patients with febrile acne conglobata exhibited negative reactions to all tested allergens and tuberculin.
Four out of five patients did not develop DNCB sensitization.
Lymphocyte transformation by PHA was normal in all patients.
Control acne patients showed positive tuberculin reactions and DNCB sensitization.

Conclusions:

Patients with febrile acne conglobata demonstrate a specific defect in delayed hypersensitivity.
This impairment in cellular immunity may play a role in the disease's severity.
Further research is needed to elucidate the exact immune mechanisms involved.

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