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Cortical facilitatory effect of mefenamic acid
Archives Internationales De Pharmacodynamie Et De Therapie
|March 1, 1980
Summary
Mefenamic acid enhances brain responses in the somatosensory cortex when administered intravenously or topically. This finding suggests the drug
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Mefenamic acid is a nonsteroidal anti-inflammatory drug.
- Previous electroencephalography (EEG) studies suggested central nervous system effects of mefenamic acid.
Purpose of the Study:
- To investigate the central actions of mefenamic acid on the somatosensory cortex.
- To determine if mefenamic acid's central effects occur at the cortical level.
Main Methods:
- Mefenamic acid was administered intravenously and locally to the cerebral cortex.
- Evoked responses were recorded in the somatosensory S1 cortex.
Main Results:
- Intravenous and topical application of mefenamic acid increased the amplitude of evoked responses in the somatosensory S1 cortex.
- This facilitatory effect indicates a direct impact on cortical processing.
Conclusions:
- Mefenamic acid exerts a facilitatory effect on neuronal activity within the somatosensory cortex.
- The study suggests that the central actions of mefenamic acid are mediated at the cortical level.