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Lichen planus: an ultrastructural study

M Medenica, A Lorincz

    Acta Dermato-Venereologica
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Ultrastructural analysis of lichen planus skin lesions reveals basal cell injury and fibrillar transformation into colloid bodies. Dermal cells also contribute to colloid body formation, suggesting a cell-mediated hypersensitivity response.

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    Area of Science:

    • Dermatopathology
    • Cell Biology
    • Immunology

    Background:

    • Lichen planus is an inflammatory condition affecting skin and mucous membranes.
    • Understanding the ultrastructural changes in lichen planus is crucial for elucidating its pathogenesis.

    Purpose of the Study:

    • To investigate the ultrastructural morphology of skin lesions in patients with lichen planus.
    • To characterize the cellular changes and the formation of colloid bodies in lichen planus.

    Main Methods:

    • Ultrastructural examination of skin biopsy specimens from 11 patients with lichen planus.
    • Detailed analysis of keratinocytes, melanocytes, and dermal infiltrate cells.

    Main Results:

    • Basal layer keratinocytes and melanocytes exhibit nuclear abnormalities and fibrillar transformation, forming colloid bodies.

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  • Dermal infiltrate cells, primarily lympho-histiocytic, show degenerative changes and contribute to colloid body formation.
  • Intercellular contact sites are frequent between dermal inflammatory cells, particularly lymphocytes and macrophages.

    • Conclusions:

    • Primary injury to basal cells during mitosis may release antigens, triggering a cell-mediated hypersensitivity reaction in lichen planus.
    • Colloid bodies originate from injured epidermal and dermal cells undergoing fibrillar transformation.
    • The findings provide insights into the cellular mechanisms underlying lichen planus pathogenesis.