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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

443
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
443
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

392
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
392
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

402
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
402
Tissue Transplantation01:24

Tissue Transplantation

1.0K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.0K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

1.1K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
1.1K
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

24.8K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
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Related Experiment Video

Updated: Jan 30, 2026

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
13:35

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

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Carcinoma in a transplanted nipple

J H Rose

    Archives of Surgery (Chicago, Ill. : 1960)
    |September 1, 1980
    PubMed
    Summary

    Nipple-sparing mastectomy tissue, when transplanted, can harbor and grow undetected breast cancer. This case highlights the risk of malignancy recurrence in autologous nipple grafts, even after initial negative biopsies.

    Area of Science:

    • Oncology
    • Surgical Oncology
    • Plastic and Reconstructive Surgery

    Background:

    • Nipple preservation during mastectomy is a common patient request for aesthetic and psychological reasons.
    • Autologous nipple grafting is a technique used in reconstructive mammoplasty following mastectomy.
    • The oncologic safety of nipple preservation and grafting requires careful consideration.

    Observation:

    • A 26-year-old woman underwent mastectomy with nipple preservation for breast cancer.
    • The harvested nipple was transplanted to the left thigh for potential future reconstruction.
    • Initial biopsy of the nipple base before transplantation showed no evidence of malignancy.

    Findings:

    • Eleven months post-transplantation, a significant mass developed within the nipple graft.

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  • An enlarged inguinal lymph node was noted adjacent to the graft site.
  • Biopsy of the nipple graft mass confirmed the presence of duct cell carcinoma, identical to the original breast cancer.

    • Implications:

    • This case underscores the potential for occult malignancy within preserved nipple tissue.
    • Autologous nipple grafts may harbor dormant cancer cells capable of later growth and metastasis.
    • Careful oncologic surveillance and potentially more extensive tissue sampling may be warranted for nipple preservation and grafting in breast cancer patients.