[Effect of extreme mechanical stimulation on structuro-functional changes in bushy interoceptors]

Synchronous morphophysiological reaction of intramural bushy receptors to an extreme mechanical stimulation produced by an increased pressure and hence, by an overdilatation of the urinary bladder wall has been studied in Rana temporaria. It has been demonstrated that the extreme mechanical factor inhibits the receptor spike activity. It is proved by: a decreased affinity of the receptors to vital methylene blue staining; changes in the form of the receptor patches; decreasing mobility of granules in the patches; increase in staining time. It is evident that energy exhaustion of the receptor as a result of overexcitement is responsible for these shifts. In the previous experiments an adequate (weaker) dilatation of the urinary bladder wall did not inhibit the receptor spike activity and morphological changes had different dynamics. The results of the two experiments are compared.