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Chloramphenicol optic neuropathy

V Godel, P Nemet, M Lazar

Archives of Ophthalmology (Chicago, Ill. : 1960)

|August 1, 1980

Summary

This summary is machine-generated.

Cystic fibrosis patients experienced optic neuropathy from chloramphenicol toxicity. Visual impairment resolved after discontinuing the drug, highlighting the importance of monitoring ocular health.

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Area of Science:

Ophthalmology
Neurology
Pharmacology

Background:

Cystic fibrosis (CF) is a genetic disorder affecting multiple organs, including the pancreas.
Chloramphenicol is an antibiotic with potential toxic side effects.
Optic neuropathy can lead to significant visual impairment.

Observation:

Three patients with cystic fibrosis presented with optic neuropathy.
The neuropathy was attributed to a toxic reaction to chloramphenicol treatment.
Ocular symptoms included reduced visual acuity, central scotomas, and red-green color vision defects.

Findings:

Increased latency in occipital evoked potentials correlated with visual impairment.
Electroretinogram showed a transient photopic decline.

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Uhthoff's sign was observed during the acute phase.

Implications:

Chloramphenicol toxicity can cause severe optic neuropathy in cystic fibrosis patients.
Prompt drug withdrawal is crucial for visual recovery.
Ophthalmological monitoring is essential for patients with cystic fibrosis receiving chloramphenicol.