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Related Experiment Videos

Penicillamine-induced pemphigus foliaceus

J K Kristensen, S Wadskov

    Acta Dermato-Venereologica
    |January 1, 1977
    PubMed
    Summary

    D-penicillamine therapy for scleroderma can induce pemphigus foliaceus and proteinuria. While proteinuria resolved after drug cessation, the autoimmune blistering disease persisted, suggesting a drug-induced autoimmune mechanism.

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    Area of Science:

    • Dermatology
    • Immunology
    • Pharmacology

    Background:

    • Scleroderma is a chronic autoimmune disease affecting connective tissue.
    • D-penicillamine is a chelating agent used in treating scleroderma and other conditions.
    • Drug-induced autoimmune conditions are a known complication of certain medications.