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Common methods, different populations. The Lipid Research Clinics Program Prevalence Study

O D Williams, R L Mowery, G T Waldman

    Circulation
    |November 1, 1980
    PubMed
    Summary
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    The Lipid Research Clinics (LRC) Program Prevalence Study collected extensive data on plasma lipids and health from over 68,000 participants. This research provides a foundation for understanding cardiovascular health indicators in diverse populations.

    Area of Science:

    • Cardiovascular epidemiology
    • Clinical chemistry
    • Public health research

    Background:

    • The Lipid Research Clinics (LRC) Program Prevalence Study was a large-scale epidemiological initiative.
    • It aimed to collect comprehensive health data across multiple international sites.

    Purpose of the Study:

    • To present the structure, populations, and methodologies of the LRC Program Prevalence Study.
    • To establish a reference framework for subsequent studies on lipid and lipoprotein levels and cardiovascular health.

    Main Methods:

    • Conducted two sequential screening examinations involving over 68,000 participants across 12 international LRCs.
    • Utilized standardized procedures for plasma lipid determination, lipoprotein cholesterol analysis, clinical chemistries, nutritional assessment, and electrocardiography.

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  • Implemented data quality enhancement procedures to ensure reliability.

    • Main Results:

    • Detailed description of major data items collected, including lipid profiles, clinical chemistries, and electrocardiographic data.
    • Discussion of the strengths and weaknesses of the study's methodology.
    • Inclusion of data from U.S., Canada, U.S.S.R., and upcoming data from Israel.

    Conclusions:

    • The LRC Program Prevalence Study established a robust dataset for cardiovascular and lipid research.
    • The study's comprehensive methodology and large sample size provide a valuable reference for epidemiological research.
    • This foundational work facilitates the interpretation of individual studies within the LRC program.