[Influencing the automatized chelesterol determination using the Liebermann-Burchard technic through selected drugs...

The ascertained influences of this cholesterol determination in vitro mentioned in the survey literature for therapeutically relevant doses are astonishingly small. In the present paper the following drugs were tested: Dextran, vitamin C, procain, chlorpromazine, methyldopa, phenacetin, fluphenazine. With the exception of methyldopa pure substance was used. In every case twelve-fold determinations with the concentrations 0.02, 0.2 and 2 mmol/l were performed. Though particularly for vitamin C and methyldopa depending on dose, as well as for all other drugs with the exception of dextran increases can be proved, these, however, remain eventually in the normal region of the method. The influence of the determination of cholesterol proposed by the drugs tested under therapeutic conditions is only of insignificant practice relevance. This is a positive evidence for the use of this method in the routine laboratory.