Related Experiment Videos
[Atypical course of human salmonellosis (author's transl)]
Abstract:
During the last few years atypical forms of human salmonellosis were observed in 27 patients. Most frequent were acute gastroenteritis with bacteraemia or septicaemia, abscess formations in various organs and septic infections with gastroenteritis Salmonellae but no demonstrable gastroenteritis. In addition there were cases of osteomyelitis, peritonitis, one case of infected hip replacement, one of infected adrenal cortical tumour, and one of infected aortic aneurysm. In 24 of the 27 patients there was an underlying disease likely to have favoured the development of such infections. Diabetes mellitus, cholelithiasis and malignant tumours were the most frequent condition. Isolation of the positive organism was obtained from various materials (blood, abscess pus, gallbladder smear, operative specimen). Chemotherapy is definitely indicated in such Salmonella infections. Often additional surgical measures, e.g. to control spread of septic foci, were necessary. Prophylactic chemotherapy is recommended for patients with risk factors in order to prevent bacteraemic-metastatic events.
Insights
Atypical human salmonellosis presents with diverse symptoms, often linked to underlying conditions like diabetes. Prompt chemotherapy and surgery are crucial for managing these severe Salmonella infections.
Area of Science:
- Infectious Diseases
- Microbiology
- Clinical Medicine
Background:
- Human salmonellosis typically manifests as acute gastroenteritis.
- Atypical presentations of Salmonella infections are increasingly recognized.
Observation:
- Twenty-seven patients presented with unusual forms of salmonellosis, including bacteremia, sepsis, and organ abscesses.
- Specific manifestations included osteomyelitis, peritonitis, and infections of prosthetic devices and tumors.
- Underlying conditions such as diabetes mellitus, cholelithiasis, and malignancies were prevalent in 24 patients.
Findings:
- Salmonella was isolated from blood, abscess pus, and surgical specimens.
- Effective treatment requires chemotherapy, often supplemented by surgical intervention to control septic foci.
- Atypical Salmonella infections can lead to severe, disseminated disease.
Implications:
- Early recognition and prompt treatment are vital for improving outcomes in atypical salmonellosis.
- Prophylactic chemotherapy is recommended for at-risk individuals to prevent invasive Salmonella events.
- Understanding these atypical forms is crucial for comprehensive infectious disease management.