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Updated: Jul 31, 2026

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
11:50

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

Published on: July 10, 2010

[R amplitude changes and ST segment lowering in the exercise ECG compared with angiographic findings (author's

W Schützenberger, F Leisch, W Herbinger

    Deutsche Medizinische Wochenschrift (1946)
    |September 12, 1980
    PubMed

    Insights

    This study compared exercise electrocardiogram (ECG) and coronary angiography in 73 patients. Combining ST lowering and R amplitude changes improved diagnostic accuracy for coronary artery disease detection.

    Area of Science:

    • Cardiology
    • Diagnostic Imaging
    • Exercise Physiology

    Background:

    • Exercise electrocardiogram (ECG) is a common non-invasive tool for diagnosing coronary artery disease (CAD).
    • Coronary angiography remains the gold standard for CAD assessment.
    • Evaluating the diagnostic performance of different ECG criteria is crucial for clinical practice.

    Purpose of the Study:

    • To compare the diagnostic accuracy of exercise ECG criteria against coronary angiography in patients with suspected CAD.
    • To assess the sensitivity and specificity of individual and combined ECG parameters.

    Main Methods:

    • Retrospective analysis of 73 patients undergoing both exercise ECG and coronary angiography.
    • Evaluation of three exercise ECG criteria: ST lowering, R amplitude change, and anginal symptoms.
    • Comparison of diagnostic performance of individual criteria and their combinations.

    Main Results:

    • Individual criteria showed varying sensitivity and specificity: ST lowering (47% sensitivity, 90% specificity), R amplitude change (58% sensitivity, 90% specificity), and anginal symptoms (60% sensitivity, 65% specificity).
    • Combining ST lowering and/or R amplitude change improved sensitivity by 11% and specificity by 15% compared to ST lowering and/or angina.
    • Utilizing all three criteria (singly or combined) yielded 91% sensitivity but reduced specificity to 55%.

    Conclusions:

    • R amplitude change effectively identifies patients with diminished exercise tolerance.
    • Combination of ST lowering and R amplitude change offers enhanced diagnostic accuracy for CAD detection via exercise ECG.
    • Exercise ECG criteria, particularly when combined, provide valuable information for CAD assessment, though careful interpretation considering specificity is necessary.

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