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Carbamazepine-10,11-epoxide determined by EMIT carbamazepine reagent
Epilepsia
|October 1, 1980
Abstract:
Carbamazepine-10,11-epoxide (CBZ-OX) was determined in physiological solutions by means of EMIT carbamazepine reagent. It was recognized as 12 to 20% of the total amount, the cross-reaction being higher at lower CBZ-OX concentrations. A correction for CBZ-OX is necessary when one wants to correlate EMIT carbamazepine values with gas-liquid chromatography values. However, this correction is relevant only for body fluids other than plasma, since the unbound fraction of CBZ-OX would greatly influence the ultrafiltrate serum ratios.