Effects of bicuculline and chlordiazepoxide on locomotor activity and avoidance performance in rats

Bicuculline, at a dose of 1 mg/kg which, per se, failed to change locomotor activity in rats, counteracts the facilitating effect induced by chlordiazepoxide (10 mg/kg). Conversely, bicuculline (1 mg/kg) does not modify the decrease of motor activity and the disruption of avoidance performance induced by this benzodiazepine derivative (20 mg/kg).