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Summary
Lactic dehydrogenase virus establishes chronic infections in Asian mice (Mus caroli), similar to common mice (Mus musculus). However, Asian mice exhibit lower viral loads and less enzyme activity during infection.
Area of Science:
- Virology
- Immunology
- Comparative Pathology
Background:
- Lactic dehydrogenase virus (LDV) is known to cause chronic infections in laboratory mice (Mus musculus).
- Understanding LDV host range is crucial for viral pathogenesis research.
Purpose of the Study:
- To investigate the susceptibility of Asian mice (Mus caroli) to LDV infection.
- To compare the course of LDV infection in Mus caroli versus Mus musculus.
Main Methods:
- Infection of Mus caroli mice with LDV.
- Monitoring of viral load (viraemia) in infected mice.
- Measurement of plasma lactate dehydrogenase (LDH) activity.
Main Results:
- LDV successfully replicated and established chronic infection in Mus caroli.
- Mus caroli showed significantly lower viraemia levels compared to Mus musculus.
- Plasma LDH activity increase was markedly reduced in infected Mus caroli.
Conclusions:
- Mus caroli serves as a host for LDV, demonstrating a broader host range for the virus.
- The observed lower viraemia and LDH activity suggest differences in host-pathogen interactions or viral replication efficiency in Mus caroli.