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Autoimmune thyroiditis in peripheral arterial disease

J Sister, R M Greenhalgh

    The Journal of Cardiovascular Surgery
    |July 1, 1980
    PubMed
    Summary
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    Peripheral arterial disease patients with high cholesterol may have undiagnosed autoimmune thyroiditis. Further investigation revealed two cases of asymptomatic thyroiditis in this subgroup, highlighting a potential link.

    Area of Science:

    • Endocrinology
    • Cardiovascular Medicine
    • Immunology

    Background:

    • Peripheral arterial disease (PAD) is a common condition often associated with cardiovascular risk factors.
    • Elevated serum cholesterol is a known risk factor for atherosclerosis and PAD.
    • Autoimmune thyroiditis is an endocrine disorder that can present asymptomatically.

    Purpose of the Study:

    • To investigate the prevalence of autoimmune thyroiditis in patients with peripheral arterial disease and hypercholesterolemia.
    • To explore potential links between these conditions.

    Main Methods:

    • Retrospective analysis of 128 patients with angiographically confirmed peripheral arterial disease.
    • Measurement of fasting serum cholesterol levels.
    • Screening for thyroid antibodies and thyroid-stimulating hormone (TSH) levels in patients with elevated cholesterol.

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    Main Results:

    • 13 out of 128 patients (approximately 10.2%) presented with raised fasting serum cholesterol.
    • Of these 13 patients, 2 were diagnosed with asymptomatic autoimmune thyroiditis based on positive thyroid antibodies and elevated TSH levels.
    • This suggests a potential comorbidity in a small subset of PAD patients.

    Conclusions:

    • A subset of patients with peripheral arterial disease and hypercholesterolemia may have undiagnosed asymptomatic autoimmune thyroiditis.
    • Screening for thyroid dysfunction could be considered in PAD patients with elevated cholesterol.
    • Further research is warranted to confirm this association and its clinical implications.