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Related Experiment Videos

A simple test for urinary lactic acid

H Bartels, W Berger

    Intensive Care Medicine
    |August 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    A new rapid test detects elevated urinary lactate, correlating with blood lactate levels. This simple method reliably identifies clinically significant hyperlactatemia using a colorimetric reaction.

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    Area of Science:

    • Biochemistry
    • Clinical Chemistry
    • Diagnostic Medicine

    Background:

    • Hyperlactatemia, indicated by elevated blood lactate levels, is a critical indicator of cellular dysfunction and poor prognosis.
    • Current methods for lactate detection can be time-consuming or require specialized equipment, limiting rapid clinical application.
    • A simple, rapid diagnostic tool for monitoring lactate levels is needed, particularly in emergency settings.

    Purpose of the Study:

    • To describe a novel, simple, and rapid test for detecting increased urinary lactate concentration.
    • To evaluate the correlation between urinary lactate levels and blood lactate levels in patients.
    • To assess the utility of the urinary lactate test in identifying clinically relevant hyperlactatemia.

    Main Methods:

    Related Experiment Videos

  • The test involves the conversion of lactic acid in urine to acetaldehyde using cesium IV.
  • Acetaldehyde then reacts with sodium nitroprusside, producing a distinct blue color indicative of lactate presence.
  • The test was validated by screening patients in an emergency ward and those with experimentally induced hyperlactatemia.

    • Main Results:

    • A significant correlation was observed between blood lactate levels and urinary lactate concentrations.
    • The developed test reliably detected increased urinary lactate in patients with clinically relevant hyperlactatemia.
    • The colorimetric response of the test was consistent with the degree of hyperlactatemia.

    Conclusions:

    • The described method provides a simple, rapid, and reliable way to detect increased urinary lactate.
    • Urinary lactate concentration serves as a viable non-invasive marker for assessing hyperlactatemia.
    • This test has potential applications in emergency medicine and critical care for rapid patient assessment.