Intrathecal and extrathecal production of antibrain antibodies in multiple sclerosis

Complement-fixing antibrain antibodies of several specificities were titrated in paired serum and CSF samples from 27 MS patients. The results indicated that the antibodies were synthesized on both sides of the blood-brain barrier in proportions that showed a great interindividual variation. It is suggested that this variation applies also to other MS-associated immunoglobulins.