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Mirex kinetics in chickens

F A Ahrens, D C Dyer, W E Lloyd

    Journal of Toxicology and Environmental Health
    |July 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    This study investigated Mirex kinetics in chickens. Results show Mirex accumulates in fat and skin, with slow elimination, suggesting avian species do not efficiently excrete this persistent organic pollutant.

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    British medical journal·2010

    Area of Science:

    • Environmental Toxicology
    • Pharmacokinetics
    • Wildlife Science

    Background:

    • Mirex is a persistent organic pollutant with known toxicity.
    • Understanding Mirex's behavior in avian species is crucial for ecological risk assessment.

    Purpose of the Study:

    • To determine the pharmacokinetic profile of Mirex in chickens.
    • To quantify Mirex accumulation and depletion in key tissues.
    • To compare avian Mirex elimination with mammalian data.

    Main Methods:

    • Administered single intravenous (30 mg/kg) and oral (300 mg/kg) doses of Mirex to chickens.
    • Analyzed blood and tissue (fat, skin) Mirex concentrations over time.
    • Fed growing chicks diets containing 1 or 10 ppm Mirex to assess depletion rates.

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    Main Results:

    • Mirex exhibited biphasic decline in blood, indicating distribution into fast and slow tissue compartments.
    • Greatest Mirex accumulation occurred in fat and skin within 2 weeks.
    • Less than 1% of the dose was excreted in 2 weeks.
    • Calculated Mirex half-lives in skin and fat were 24.8 and 31.5 days, respectively.
    • Tissue concentration decrease was primarily due to growth dilution, not excretion.

    Conclusions:

    • Chickens exhibit slow Mirex elimination, with significant accumulation in fat and skin.
    • Growth dilution is a major factor in apparent tissue concentration decrease in growing birds.
    • Avian species likely do not eliminate Mirex more efficiently than mammals.