Malignant degeneration of a juvenile laryngeal papilloma--a follow-up study

The patient, a non-smoking woman aged 51, had been suffering from recurrent juvenile papilloma for 38 years. After eight years during which there was increasing atypia, an extensive malignant papillary tumor, with extralaryngeal spread, was diagnosed. Only seven cases of malignant degeneration of non-irradiated juvenile laryngeal papilloma have been reported; at least four were heavy smokers.