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Metastatic basal cell carcinoma

E F Scanlon, D D Volkmer, M A Oviedo

    Journal of Surgical Oncology
    |January 1, 1980
    PubMed
    Summary
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    Metastatic basal cell carcinoma, though rare, may spread via the interstitial route, challenging current cancer spread theories. This finding suggests a common pathway for tumor dissemination with significant treatment implications.

    Area of Science:

    • Oncology
    • Dermatopathology

    Background:

    • Basal cell carcinoma (BCC) is a common skin cancer.
    • The primary mode of BCC spread is typically direct extension.
    • Metastatic BCC is historically rare, with limited reported cases.

    Observation:

    • Five new cases of metastatic basal cell carcinoma are presented.
    • These cases suggest spread via the interstitial route.
    • This challenges the established understanding of cancer metastasis.

    Findings:

    • The interstitial embolic spread of cancer is generally considered uncommon.
    • These five cases provide strong evidence supporting interstitial spread as a potential common route for BCC.
    • This challenges standard oncological teaching regarding cancer dissemination.

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    Implications:

    • The concept of interstitial embolic spread has significant implications for understanding BCC behavior.
    • This route of spread may be more common than previously thought.
    • Revisiting treatment strategies for basal cell carcinoma and potentially other cancers may be necessary.