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Intercorrelations among plasma high density lipoprotein, obesity and triglycerides in a normal population
Lipids
|September 1, 1980
Summary
Increased body fatness is linked to lower levels of high-density lipoprotein (HDL) cholesterol, particularly the HDL2 subfraction, and higher triglycerides. These relationships persist even after accounting for other factors.
Area of Science:
- Cardiovascular Health
- Metabolic Syndrome
- Lipid Metabolism
Background:
- Obesity is a growing public health concern.
- Understanding the relationship between body fat and lipid profiles is crucial for cardiovascular risk assessment.
Purpose of the Study:
- To investigate the interrelationships among various measures of body fatness, plasma triglycerides, and high-density lipoproteins (HDL) in normal adults.
- To determine the association between specific HDL subfractions (HDL2b, HDL2a, HDL3) and body fatness.
Main Methods:
- 131 normal adult subjects (men and women across different age groups) were studied.
- Anthropometric measures included skinfolds, weight/height indices, and girth measurements.
- HDL was fractionated into HDL2b, HDL2a, and HDL3 using ultracentrifugation and schlieren patterns.
Main Results:
- A strong correlation was observed among different fatness measures.
- Fatness measures were negatively correlated with total HDL and specifically HDL2, but not HDL3.
- Triglyceride concentration showed an inverse correlation with HDL2.
- Combined obesity measures improved correlations with HDL, and controlling for fatness did not diminish triglyceride-HDL2 correlations.
Conclusions:
- Body fatness is inversely associated with HDL2 levels and positively associated with triglycerides.
- HDL2, but not HDL3, is sensitive to changes in body fatness.
- These findings highlight the importance of body composition in modulating lipid profiles and cardiovascular risk.