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Related Experiment Videos

Computed tomography in Alexander's disease

I M Holland, B E Kendall

    Neuroradiology
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    This study presents two cases of Alexander's disease, a rare neurological disorder. Unique computed tomographic findings in these patients strongly support the diagnosis when combined with clinical symptoms.

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    Area of Science:

    • Neurology
    • Radiology
    • Pediatrics

    Background:

    • Alexander's disease is a rare, progressive, often fatal, neurological disorder.
    • It is characterized by the widespread presence of Rosenthal fibers in the white matter of the brain.

    Observation:

    • Two pediatric cases with biopsy-proven Alexander's disease were analyzed.
    • Specific computed tomographic (CT) imaging features were observed in these cases.

    Findings:

    • The observed CT changes were unique and not previously reported in other conditions.
    • These distinctive radiological findings, in conjunction with clinical presentation, significantly aid in diagnosing Alexander's disease.

    Implications:

    • The study highlights the diagnostic value of specific CT findings in Alexander's disease.

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  • This can lead to earlier and more accurate diagnosis, potentially improving patient management.