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Reduced urinary estriol levels with erythromycin therapy
Obstetrics and Gynecology
|September 1, 1980
Summary
Erythromycin can interfere with urinary estriol measurements during pregnancy. This finding is important for accurate pregnancy monitoring when using this common antibiotic.
Area of Science:
- Pharmacology
- Obstetrics
- Clinical Chemistry
Background:
- Urinary estriol levels are a key indicator of fetal well-being during pregnancy.
- Several medications are known to affect estriol measurements, potentially leading to misinterpretation.
Observation:
- This report identifies erythromycin as a pharmacologic agent that interferes with urinary estriol levels.
- The interference mechanism is not detailed but highlights a potential clinical confounder.
Findings:
- Erythromycin use is associated with altered urinary estriol concentrations.
- This interference can impact the interpretation of established pregnancy monitoring tests.
Implications:
- Clinicians should be aware of erythromycin's potential to affect estriol tests.
- Alternative methods or adjusted interpretations may be necessary for pregnant patients on erythromycin.