[Factors favoring anaphylactic reactions to general anesthetics]

The prevention of anaphylactic reactions to general anesthetics depends on the definition of a high risk group owing to special risk factors in these subjects. This study based on a study of the world literature over 20 years and on the cases of anaphylactic reaction observed in Nancy (more than 30) led the authors to carry out a special study of 7 with an atopic background, a history of drug allergy of immediate type, the repetition of general anesthetics at short intervals, latent spasmophilia, aptitude to histamine liberation, and/or hyper-reactivity to histamine, type of anesthesia and association of various factors. This method of approach permits in turn a prevention of complications by appropriate premedication.