Post-swim grooming in mice inhibited by dopamine receptor antagonists and by cannabinoids

After a period of swimming, mice engaged in vigorous grooming activity. This behaviour was inhibited in a dose dependent manner by dopamine receptor antagonists and by the cannabinoids, delta 9-tetrahydrocannabinol and cannabinol. Cannabidiol was inactive. It is suggested that the post-swin grooming behaviour involves a dopaminergic mechanism. The mechanism of action of the cannabinoids on this behaviour is unknown.