Isoproterenol-induced enhancement of myocardial glucose-6-phosphate dehydrogenase

Isoproterenol enhanced the activity of glucose-6-phosphate dehydrogenase and the availability of 5-phosphoribosyl-1-pyrophosphate in the rat myocardium, which indicates an increased flow through the hexose monophosphate shunt. The stimulatory effect of isoproterenol on cardiac glucose-6-phosphate dehydrogenase activity, could be prevented by beta-receptor blockade with atenolol, but not by the calcium-antagonistic compound D 600.