[Superoxide dismutase and rheumatoid arthritis. Study of a series of 6 cases]

The authors present a short series (6 cases) of serum positive rheumatoid arthritis, treated by I.M. injections (5 cases) or intra-articular injections (one case) of dismutase superoxide of bovine origin. The treatment was stopped in one case for local intolerance. Four cases treated for four months by the intramuscular route, were uninfluenced by the treatment, nor was the patient treated by the intra-articular route. The laboratory parameters (E.S.E., Rose Waaler reaction) were not modified. On the other hand, the lymphocyte fragility in culture was improved. The good tolerance of this compound in the laboratory will permit further trials in higher dosage.