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[Euphyllin retard and "exercise-induced" asthma]

M Scherrer, H Bachofen, K Kyd

    Schweizerische Medizinische Wochenschrift
    |June 21, 1980
    PubMed
    Summary
    This summary is machine-generated.

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    Theophylline slow-release tablets effectively protect against exercise-induced asthma only when plasma concentrations exceed 10 microgram/ml. Monitoring these levels is crucial for effective treatment and avoiding side effects.

    Area of Science:

    • Pulmonology
    • Clinical Pharmacology

    Background:

    • Exercise-induced asthma (EIA) is a common condition affecting individuals with asthma.
    • Theophylline is a bronchodilator used in asthma management, but its efficacy in EIA requires investigation.

    Purpose of the Study:

    • To evaluate the protective effect of theophylline slow-release tablets (Euphyllin retard) against exercise-induced asthma.
    • To determine the relationship between plasma theophylline concentrations and its protective efficacy.

    Main Methods:

    • A double-blind, placebo-controlled crossover study involving 16 patients with EIA.
    • Patients underwent treadmill exercise tests after receiving either Euphyllin retard or placebo.
    • Plasma theophylline levels were measured using tritium radioimmunoassay.

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    Main Results:

    • Euphyllin retard demonstrated a significant protective effect against EIA only in patients with plasma theophylline concentrations above 10 microgram/ml.
    • Patients with lower plasma concentrations (< 6.2 microgram/ml) showed no significant protection compared to placebo.
    • Side effects were noted at concentrations exceeding 15 microgram/ml.

    Conclusions:

    • Plasma theophylline concentrations above 10 microgram/ml are necessary for effective protection against exercise-induced asthma.
    • Individualized monitoring of plasma theophylline levels is essential due to variable pharmacokinetics.
    • Therapeutic drug monitoring is recommended to optimize efficacy and minimize adverse events.