[Increased sebum secretion due to oral administration of zinc sulfate]

In 87 patients hospitalized for chronic leg ulcers the effect of oral zinc on sebum secretion was determined. The patients were divided into three groups according to serum zinc concentrations. Patients with zinc levels in the upper normal range (Zn greater than or equal to 1.0 mg/l) were not treated. Patients with zinc levels in the lower normal range (Zn < 1.0 mg/l) received either three daily doses of 220 mg zinc sulphate or a placebo. The zinc-treated group displayed significantly increased sebum secretion. This effect was more marked in males, and may be due to a zinc-induced rise in plasma testosterone. Indications for oral zinc in dermatological conditions are discussed.