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Practical application of patterned visual evoked responses in multiple sclerosis

K Kayed, O Røsjø, B Kåss

    Acta Neurologica Scandinavica
    |December 1, 1978
    PubMed
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    Pattern reversal visual evoked potentials (VEP) effectively identify multiple sclerosis (MS) by detecting abnormalities in visual pathways. This rapid technique is valuable for diagnosing suspected MS cases in clinical neurophysiology labs.

    Area of Science:

    • Neuroscience
    • Clinical Neurophysiology

    Background:

    • Multiple sclerosis (MS) is a demyelinating disease affecting the central nervous system.
    • Visual evoked potentials (VEP) are sensitive to optic nerve and visual pathway dysfunction.
    • Standardized VEP testing is crucial for accurate MS diagnosis.

    Purpose of the Study:

    • To evaluate the utility of pattern reversal visual evoked potentials (VEP) in diagnosing multiple sclerosis (MS).
    • To establish normal VEP values and compare them with existing literature.
    • To assess the diagnostic yield of VEP in patients with suspected MS.

    Main Methods:

    • Pattern reversal visual evoked potentials (VEP) were recorded from 72 healthy controls and 60 MS patients.
    • A commercial TV and EMG machine were used for visual stimulation and response averaging.

    Related Experiment Videos

  • VEP parameters including latency and inter-eye differences were analyzed.

    • Main Results:

    • Established normative VEP values for latency and inter-eye differences in the control group.
    • Observed significant VEP abnormalities in patients with multiple sclerosis.
    • Demonstrated the effectiveness of VEP in identifying visual pathway involvement in MS.

    Conclusions:

    • Pattern reversal VEP is a valuable, rapid, and accessible tool for investigating suspected multiple sclerosis.
    • Standardized control studies are essential for reliable VEP interpretation in each laboratory.
    • VEP testing aids in the early detection and diagnosis of MS-related visual dysfunction.