Excretion of dietary butylated hydroxytoluene by the rat
Abstract:
The concentration of phenols in the urine or feces of rats receiving a diet containing 1.00% butylated hydroxytoluene (BHT) for 10 days was determined colorimetrically. The cumulative intake of BHT was approx. 5.0 mmol/rat for 10 days. The total amount of phenols excreted in urine and feces was 3.65 mmol/rat for 10 days, i.e. 73% of the administered BHT. About 48% was excreted in the urine, and 25% in the feces; about 30%, or 11%, of the dose appeared to be present as unconjugated phenols in the urine, or feces, respectively. The major metabolite detected was 3,5-di-tert-butyl-4-hydroxybenzoic acid (BHT acid).
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