[Acid reduction after SPV and after H2 receptor blocking substance cimetidine. Comparative studies in Shay-rats)]

The effect of a complete selective proximal vagotomy on stomach acidity has been compared experimentally to that of the H2 receptor blocking agent cimetidine in the rat. Both methods produced a significant reduction of total acid as compared to controls, a reduction to 0.5 % for cimetidine and to 0.1 % for SPV. The acid reduction following SPV is a result of decreased production of stomach fluid as well as a decrease in degree of acidity. The acid reduction following administration of cimetidine is mainly a result of an increase in pH without any change in volume of stomach fluid production.