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Human toxocariasis in a rural community
American Journal of Diseases of Children (1960)
|October 1, 1980
Summary
A study found over half of participants had Toxocara canis antibodies, with higher rates in adults. Despite positive antibody titers, clinical toxocariasis was uncommon, suggesting asymptomatic infections.
Area of Science:
- Parasitology
- Epidemiology
- Immunology
Background:
- Toxocara canis infections are common in dogs and can transmit to humans.
- Human toxocariasis can cause visceral larva migrans and ocular larva migrans.
Purpose of the Study:
- To determine the seroprevalence of Toxocara canis infection in a Pennsylvania community.
- To investigate the association between seropositivity and clinical manifestations of toxocariasis.
Main Methods:
- A serologic survey using enzyme-linked immunosorbent assay (ELISA) to detect antibodies to Toxocara canis.
- Questionnaires collected demographic data and medical history.
- Physical examinations and laboratory tests were performed on seropositive individuals.
Main Results:
- 54% of 43 participants had positive Toxocara canis antibody titers (≥1:32).
- Seropositivity was highest in adults (≥18 years).
- Despite positive titers, clinical signs of toxocariasis were not observed in most individuals.
Conclusions:
- High seropositivity rates for Toxocara canis indicate widespread exposure in the community.
- Clinical toxocariasis appears to be uncommon, even with significant antibody titers.
- Further research is needed to understand the implications of asymptomatic Toxocara infections.