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A genetic study of panic disorder pedigrees

D L Pauls, K D Bucher, R R Crowe

    American Journal of Human Genetics
    |September 1, 1980
    PubMed
    Summary

    Genetic analysis of 19 families indicates panic disorder is an autosomal dominant trait. This pattern holds true even when excluding families with mitral valve prolapse, suggesting a consistent inheritance pattern for panic disorder.

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    Area of Science:

    • Psychiatry and Genetics
    • Human Genetics
    • Clinical Psychology

    Background:

    • Panic disorder is a significant psychiatric condition with complex etiology.
    • Previous studies have suggested a genetic component to panic disorder.
    • The role of comorbid conditions, such as mitral valve prolapse, in panic disorder inheritance is not fully understood.

    Purpose of the Study:

    • To investigate the mode of inheritance for panic disorder.
    • To determine if panic disorder is transmitted as an autosomal dominant trait.
    • To examine the influence of mitral valve prolapse on the inheritance pattern of panic disorder.

    Main Methods:

    • Conducted pedigree analysis on 19 kindreds diagnosed with panic disorder.
    • Collected family history data to trace the occurrence of panic disorder across generations.
    • Performed statistical analysis to assess the mode of genetic transmission.

    Main Results:

    • Pedigree analysis of all 19 kindreds strongly suggests that panic disorder is transmitted as an autosomal dominant trait.
    • Excluding seven kindreds ascertained through a proband with mitral valve prolapse did not alter the findings.
    • Panic disorder without mitral valve prolapse also appears to be transmitted as an autosomal dominant trait.

    Conclusions:

    • Panic disorder exhibits a clear autosomal dominant inheritance pattern.
    • The presence of mitral valve prolapse does not appear to be a prerequisite for the autosomal dominant transmission of panic disorder.
    • These findings have implications for genetic counseling and understanding the biological underpinnings of panic disorder.

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