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Drug interferences with tests performed by a 12-channel autoanalyzer
American Journal of Hospital Pharmacy
|October 1, 1980
Summary
This review identified clinically significant drug interferences with common laboratory tests. It highlights the need for labs to verify drug interactions specific to their autoanalyzer methods.
Area of Science:
- Clinical Chemistry
- Pharmacology
- Laboratory Medicine
Background:
- Drug interferences can affect routine laboratory test results.
- A comprehensive review of existing literature is needed to identify clinically relevant interactions.
Purpose of the Study:
- To review and critically evaluate reported drug interferences with 12-channel autoanalyzer tests.
- To identify clinically significant drug-laboratory test interactions.
Main Methods:
- Systematic review of literature on drug interferences with specific laboratory tests.
- Evaluation of study design (in vitro/in vivo), medium, drug levels, and clinical significance.
- Focus on tests including glucose, cholesterol, albumin, alkaline phosphatase, SGOT, and chloride.
Main Results:
- Identified clinically significant interactions: aminosalicylic acid with glucose, gamma globulins with cholesterol, sulfonamides/paramethadione with albumin, placental albumin with alkaline phosphatase, erythromycin estolate/aminosalicylic acid with SGOT.
- Possible interference noted for bromide ions with chloride measurement.
Conclusions:
- The review significantly narrowed the list of clinically relevant drug interferences.
- Laboratories must assess the relevance of drug interactions to their specific methods and patient populations.