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Steroid secretion by the postmenopausal ovary

C Longcope, R Hunter, C Franz

    American Journal of Obstetrics and Gynecology
    |November 1, 1980
    PubMed
    Summary
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    Postmenopausal ovaries contribute significantly to testosterone production in about half of women and estradiol in less than 20%. Other steroid secretions were not evident, with no clear clinical indicators.

    Area of Science:

    • Endocrinology
    • Reproductive Biology
    • Gynecology

    Background:

    • Ovarian steroidogenesis is crucial throughout reproductive life.
    • Understanding postmenopausal ovarian function is important for hormone replacement therapy and managing age-related conditions.
    • Previous research on postmenopausal ovarian steroid secretion is limited.

    Purpose of the Study:

    • To quantify ovarian steroid secretion in postmenopausal women.
    • To determine which specific steroids are secreted by the postmenopausal ovary.
    • To investigate the contribution of ovarian secretion to circulating steroid levels.

    Main Methods:

    • Measurement of steroid concentrations in arterial and ovarian venous blood.
    • Study conducted on 42 postmenopausal women undergoing hysterectomy.

    Related Experiment Videos

  • Analysis of concentration gradients across the ovary for various steroids.

    • Main Results:

    • Ovarian secretion gradients were observed for testosterone (21/42 women), androstenedione (16/42), estradiol (15/42), estrone (8/42), and dehydroepiandrosterone (3/42).
    • Ovarian secretion was estimated to contribute significantly to testosterone production in ~50% of women and estradiol in <20%.
    • No evidence of ovarian secretion for dihydrotestosterone, estrone sulfate, or dehydroepiandrosterone sulfate was found.

    Conclusions:

    • Postmenopausal ovaries can be a significant source of testosterone and, to a lesser extent, estradiol.
    • The contribution of other measured steroids (androstenedione, estrone, DHEA) to overall production is likely minimal.
    • No clinical factors were identified to predict which women exhibit ovarian steroid secretion.