[EEG-effects of pethidine-promethazine. Study on 16 patients (author's transl)]

Changes of EEG and CEEG have been studied in two groups of patients premedicated with pethidine-promethazine (dosage: 50 mg/25 mg). The study group A consisted of patients whose age ranged from 20 to 50 years; in study group B the patients age was above 70 years. Continous EEG and CEEG observation ranged from 15 minutes to several hours in a few patients. Changes in clinical behaviour were recorded. Blood pressure - pulserate - measurements were taken at regular intervals. The base line electroencephalogram of thirteen patients was normal. One dialysis-patient of group A and two old patients of group B showed deviations from normal. Characteristic changes in the electroencephalogram after the tested premedication were a decline of alpha amplitude or in primarily abnormal electroencephalographic recordings a narrowing of the frequency band in higher parts, and additionally and increase of delta/theta-activity. These changes lasted several hours. In good correlation to these findings were the clinical effects of sedation and sleep. Side effects were not seen. Remarkable changes of blood pressure and pulserate were not observed.