Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic models of reading disability

F I Lewitter, J C DeFries, R C Elston

    Behavior Genetics
    |January 1, 1980
    PubMed
    Summary

    Reading disability (RD) shows genetic heterogeneity, with evidence for a major recessive gene in families with female probands. Environmental factors may also influence RD, particularly in children.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    MAXIMUM VARIANCE LINEAR COMBINATIONS FROM PHENOTYPIC, GENETIC, AND ENVIRONMENTAL COVARIANCE MATRICES.

    Multivariate behavioral research·2016
    Same author

    Factor Analysis Of Genetic And Environmental Correlation Matrices.

    Multivariate behavioral research·2016
    Same author

    Multivariate Familial Analysis of Cognitive Measures in the Colorado Family Reading Study.

    Multivariate behavioral research·2016
    Same author

    Disruption of sonic hedgehog signaling in Ellis-van Creveld dwarfism confers protection against bipolar affective disorder.

    Molecular psychiatry·2014
    Same author

    Genome-wide screening for DNA variants associated with reading and language traits.

    Genes, brain, and behavior·2014
    Same author

    Gender differences in cognitive abilities of reading-disabled twins.

    Annals of dyslexia·2013

    Area of Science:

    • Genetics
    • Developmental Psychology
    • Pediatrics

    Background:

    • Reading disability (RD) is a complex neurodevelopmental disorder.
    • Understanding the genetic and environmental underpinnings of RD is crucial for effective interventions.
    • Previous studies suggest a potential genetic component to RD, but its etiology remains debated.

    Purpose of the Study:

    • To investigate the genetic heterogeneity of reading disability (RD).
    • To determine if specific genetic models fit the observed inheritance patterns in families.
    • To explore potential differences in RD manifestation between children and adults.

    Main Methods:

    • Segregation analysis using the Elston and Yelverton (1975) technique was applied to data from 133 reading-disabled children and their families.
    • Data were analyzed across four subsets: all families, families with male probands, families with female probands, and families with severely affected probands.
    • Children's data were compared with data from all family members to assess potential age-related differences in manifestation.

    Main Results:

    • The study found evidence supporting etiological heterogeneity in reading disability.
    • A major recessive gene model was compatible with data from families with female probands.
    • Analyses of children's data alone suggested both genetic and environmental contributions to RD.

    Conclusions:

    • Reading disability is etiologically heterogeneous, indicating multiple underlying causes.
    • A significant recessive genetic factor may contribute to RD, particularly in certain family structures (e.g., those with female probands).
    • Environmental influences likely play a role in the development of RD, especially when considering children's data independently.

    Related Experiment Videos