Effects of enflurane on cardiovascular function in dogs with induced chronic mitral valve disease

The effect of enflurane on cardiovascular function was investigated in normal dogs and in dogs with chronic heart failure because of induced mitral valve disease (MVD). No significant changes were observed in heart rate (HR), right atrial pressure (RAP) and total systemic vascular resistance (TSVR) in normal dogs. However, significant decreases in HR and increases in RAP and TSVR were observed in dogs with MVD. There were no changes in pulmonary arterial pressure and left ventricular end-diastolic pressure in either group. Cardiac output, cardiac index, arterial pressure, left ventricular work index and left ventricular dp/dt and dp/dtIIP showed a concentration-dependent decrease in both groups but the changes were greater in dogs with MVD.