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Maturation of normal human epidermis without an ordered structure

P R Bergstresser, S L Chapman

    The British Journal of Dermatology
    |June 1, 1980
    PubMed
    Summary
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    Corneocyte columns, or stacked skin cells, are common in hamsters and mice but rare in normal human skin, despite previous reports. This study found no evidence of these structures in human forearm, back, or thigh skin.

    Area of Science:

    • Dermatology
    • Cell Biology
    • Histology

    Background:

    • Corneocyte columns, a specific arrangement of keratinocytes, have been observed in some mammalian species.
    • Previous reports suggest their presence in human skin, but their prevalence and typical locations remain unclear.

    Purpose of the Study:

    • To investigate the occurrence and distribution of corneocyte columns in mammalian epidermis.
    • To compare the presence of corneocyte columns in rodent models with normal human skin.

    Main Methods:

    • Epidermal whole mounts from hamster and mouse ears were prepared.
    • Skin biopsies were obtained from three sites (forearm, back, thigh) of normal human volunteers.
    • Corneocyte columns were assessed visually using light microscopy.
    • Statistical cluster analysis was applied to the distribution of superficial nucleated keratinocytes.

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    Main Results:

    • Corneocyte columns and nuclear clustering were consistently detected in hamster and mouse epidermis.
    • In contrast, corneocyte stacking was never observed in human skin biopsies.
    • Statistical analysis did not demonstrate significant nuclear clustering in the human skin samples.

    Conclusions:

    • Corneocyte columns regularly occur in the epidermis of certain mammalian species like hamsters and mice.
    • These structures are not commonly found in the sampled sites of normal human skin.
    • The findings suggest species-specific differences in epidermal organization and keratinization patterns.