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Oestradiol in saliva during the menstrual cycle
British Journal of Obstetrics and Gynaecology
|July 1, 1980
Summary
Saliva oestradiol levels accurately mirror blood levels throughout the menstrual cycle. This finding suggests salivary analysis can predict menstruation and aid women when blood draws are difficult.
Area of Science:
- Reproductive endocrinology
- Biomarker analysis
Background:
- Monitoring hormonal fluctuations during the menstrual cycle is crucial for reproductive health.
- Traditional methods often involve invasive blood sampling.
Purpose of the Study:
- To assess the correlation between salivary and blood oestradiol levels.
- To determine if salivary oestradiol can predict ovulation and the onset of menstruation.
Main Methods:
- Saliva samples were collected throughout the menstrual cycle from sixteen women.
- Blood samples were analyzed mid-cycle to identify the luteinizing hormone peak for ovulation timing.
- Oestradiol concentrations were measured in both saliva and blood.
Main Results:
- Salivary oestradiol levels demonstrated a pattern consistent with blood oestradiol levels.
- The peak oestradiol concentration in saliva accurately predicted the timing of the subsequent menstrual period.
Conclusions:
- Saliva analysis provides a non-invasive and accurate method for monitoring oestradiol levels.
- Salivary oestradiol measurement is a viable tool for predicting menstrual cycle events, especially when serial venepuncture is not feasible.