[Effect of nonachlazine on the cardiac component of baroreceptor reflexes in unanesthetized cats]

Nonachlazin in doses of 1 and 6 mg/kg provoked a rise in the arterial pressure of cats by 7--20 mm Hg. Administration of 1 mg nonaclazin into the IV ventricle induced a similar elevation of arterial pressure. Premedication with propranolol (1--3 mg/kg) did not prevent the pressor reaction. In half of the experiments, nonachlazin (6 mg/kg) produced an appearance of Meyer's waves and inhibition of the cardiac component of the barorecptor reflex that is not related to the potentiation of the sympathetic effects on the heart.